Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Chemical explosion, COVID-19, and environmental justice: Insights from low-cost air quality sensorsResearch article Published on 2022-11-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] addition affecting Air quality monitoring Analysis anthropogenic association Chemical Community company comparable Concentration concentrations COVID-19 Critical disaster environmental justice EPA examined finding greater Houston identify indicate Industrial fire accident information insight ITC lockdown Low-cost sensor measure MONITOR monitors objective observation Particulate matter positive protection Regulatory Sociodemographic terminal Variation [DOI] 10.1016/j.scitotenv.2022.157881 [Article Type] Research article
Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution PerspectivesArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] analysis analyzed antiviral drug catalytic category cysteine eight electrophilic enzyme example highlighting in silico in vitro in vivo inhibitor inhibitors insight involved mechanism Pathways protease protocols provided reactive relationship Replication reported SARS-CoV-2 Scientific community selective target targeting the SARS-CoV-2 virus without affecting [DOI] 10.1021/acs.jmedchem.2c01005 PMC 바로가기
Performing under Pressure: Insights into the Diagnostic Testing Burden at a UK National Health Service Clinical Virology Laboratory during the SARS-CoV-2 PandemicArticle Published on 2022-10-122022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] burden clinical clinical sample COVID-19 Department detect diagnostics dramatic increase genomic Host immune response increase in information insight Laboratory Logistic maintain National Health Service NHS NHS laboratories NHS laboratory non-SARS-CoV-2 Novel coronavirus pandemic Performing routine SARS-CoV-2 SARS-CoV-2 testing Testing testing. the SARS-CoV-2 viral infection Virology virus [DOI] 10.3390/v14102233 PMC 바로가기
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillanceArticle Published on 2022-10-072022-11-15 Journal: Science (New York, N.y.) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome African Beta coronavirus country Delta diagnostics dispersal faster genomes genomic Health heterogeneous nature highlight increase in Infectious disease insight Investment limitation Local pandemic proportions SARS-CoV-2 SARS-CoV-2 epidemic sequence Sequencing Surveillance Threats turnaround time variant virus [DOI] 10.1126/science.abq5358 PMC 바로가기
Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial계층적 복합 종점을 기반으로 한 연구의 설계 및 분석: DARE-19 시험의 통찰력Article Published on 2022-09-012022-09-11 Journal: Therapeutic innovation & regulatory science [Category] 임상, [키워드] accompanied Analysis analyzed cardiometabolic Cardiometabolic risk factors clinical endpoint Clinical endpoints Clinical outcome clinical outcomes clinically component components Composite composite endpoint COVID-19 COVID-19 pneumonia Dapagliflozin described detectable disease Effect Endpoint example flexible handling Hierarchical composite endpoints hospitalized patient hospitalized patients ICH include inhibitor insight Interpretation mechanism mechanism of action Missing data offered Pneumonia power primary endpoints randomized trial ranking Sample size SGLT2 inhibitors statistical suggested the primary endpoint therapeutic to define Treatment Trial Win odds. with COVID-19 [DOI] 10.1007/s43441-022-00420-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and Skin: New Insights and PerspectivesArticle Published on 2022-08-312022-11-15 Journal: Biomolecules [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 mRNA ACE2 receptor adopted Affect appear article association cell population Cohort conducted control group COVID-19 database dermatopathology disease eccrine sweat glands epidermal expression fibroblast Future globe health system healthy controls immune immunolabeling implicated inclusion criteria insight literature review manifestation Manifestations mechanism molecular New nine no significant difference pandemic performed receptor report researcher Respiratory system SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2-positive patient skin biopsies skin. staining statistically TMPRSS2 Topic two groups [DOI] 10.3390/biom12091212 PMC 바로가기
Antibody-Mediated Immunogenicity Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Following Priming, Boosting, and Hybrid Immunity: Insights From 11 Months of Follow-up of a Healthcare Worker Cohort in Israel, December 2020-October 2021프라이밍, 부스팅 및 하이브리드 면역에 따른 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 항체 매개 면역원성: 이스라엘 의료 종사자 집단의 11개월 추적 관찰에서 얻은 통찰력, 2020년 12월-2021년 10월Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome Against age all age group all age groups anti-S Antibody titer Breakthrough infection circulating Cohort comparable coronavirus coronavirus 2 coronavirus disease COVID-19 decrease described dose doses geometric mean concentration GMC HCW HCWs healthcare worker highlight hybrid IgG IgG level IgG levels IgG titer Immunity immunogenicity Immunoglobulin individual infected individual infected individuals Infection initial insight Israel Month participant PCR polymerase chain proportion Protective Quantitative re-infected Reinfection remained respiratory reversed S1/S2 SARS-CoV-2 subsequent tested timepoint uninfected vaccination Vaccine vaccine immunogenicity Vaccines Vaccines. waned worker [DOI] 10.1093/cid/ciac212 PMC 바로가기 [Article Type] Article
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
Defying convention in the time of COVID-19: Insights into the role of γδ T cellsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome adaptive immune responses aminobisphosphonates COVID-19 antiviral role Autoimmunity caused Cell circulating clearance Clinical outcome complex contribute coronavirus Coronavirus disease 2019 COVID-19 Critical Cytokine storm demonstrated disease Diseases function Gamma gamma delta (γδ) T cells immune response impede Infection Innate immunity innate immunity. insight less lung mucosal tissues Patient respiratory viral infection SARS-CoV-2 SARS-COV-2 infection severe cases Surveillance T cell T cell response T lymphocyte [DOI] 10.3389/fimmu.2022.819574 PMC 바로가기